
Prof. Dr. Helene Kretzmer, professor for computational genomics and recipient of the DRS Supervision Award for outstanding PhD supervision, shares what really matters when it comes to good supervision: trust, clear communication, and flexibility in dealing with different work styles. She talks openly about her own experiences and challenges in academia and gives insights into how she juggles research and teaching. Plus: why mistakes matter – and why a healthy work-life balance is essential in science.
HIGHLIGHTS
“Don’t be afraid to fail. Find your own passion, what you want to do and try things out. And then you will find the topic you’re curious about. And once you have this, you will be able to do great research on it. So, you know, you will grow into the scientific role.”
“Failing itself is not the big problem. Because if we don’t fail, we didn’t try things out of the box. And I think that’s part of research, trying things that are not streamlined and have been often done before.”
“An unhealthy relationship between supervisor and PhD student over an extended period of three or four years, where both sides are frustrated, is simply extremely painful.”
Prof. Dr. Helene Kretzmer
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INTRO
Welcome to the DRS podcast, the podcast for doctoral researchers at Freie Universität Berlin. I’m Dr. Marlies Klamt and today’s episode is all about one of the most important relationships in any doctoral journey, the relationship between PhD candidates and their supervisors. My guest is Professor Dr. Helene Kretzmer, who received the DRS Supervision Award for outstanding doctoral supervision, an award nominated by PhD researchers themselves. In this conversation, we explore what makes a great PhD supervisor, how to build a successful working relationship, and what both doctoral candidates and supervisors can do to make the doctoral journey a positive and productive experience.
Professor Kretzmer shares her thoughts on why supervision isn’t a one-size-fits-all approach, how she adopts two different working styles, and why trust and open communication are essential for a successful PhD. We also talk about her personal experiences, how she found her way into academia, the defining moment that sparked her interest in research, and her perspective on work-life balance in academia. If you’re a PhD researcher looking for guidance, an aspiring professor wondering how to supervise doctoral candidates, or if you’re simply curious about what makes an excellent PhD experience, this episode is for you. Let’s get started.
Interview
Welcome, Professor Kretzmer. It’s great to have you here today. Before we dive into the topic of good doctoral supervision, how would you introduce yourself, what do you do professionally, and what motivates you in your work?
Thank you very much. So what I do in my general daily work, or the research that my group does, is quite interdisciplinary. And we’re pretty much at the intersection between bio and medical informatics. And we’re basically working with a variety of different tools of sequencing data, different layers of regulation, different methods, using, for example, single-cell and long-read sequencing. And yeah, we mix basically them with different types of computational strategies. And on the one hand, we’re then interested in understanding how the epigenome regulates health and disease cells. So, for example, how does a cancer cell differ from its benign counterpart?
And on the other side, we’re a bit more translational. So, we try to utilize all the knowledge that we and others acquire to then develop new methods and models. So, for example, classifying tumour entities. And then by this, we try to integrate basically these two sides, basic and translational research, and our far-fetched aim would be then to improve patient care and improve disease diagnostics. And what drives me, I think, is this really interdisciplinary work where we work with a variety of different people. So clinicians, other bioinformaticians, informaticians, also clinicians and biologists. So basically working together, everyone brings their own type of expertise. And all of that becomes, I think, quite powerful and then really an impact on the long stretch, at least we hope, on human beings and patients in care situations.
That sounds very interesting, and I know that in your research you also work with PhD candidates and you recently won the DRS Supervision Award. Congratulations! Do you remember when you first heard about it? Where were you and how did you feel?
Thank you very much. Yes, I was actually overwhelmed. So it was, it was very cute because I was sitting in the team meeting when the email came and we were basically wrapping up and with half an eye, I saw this email popping up with the headline, more or less stating that. And I didn’t want to react because I didn’t know really what was the remaining content of that email, but it had like kind of a gut feeling what it was about. So yeah, I was really touched because for me, it’s very important to have a research group that is happy and loves what they are doing. And then getting such an incredibly amazing and nice and friendly feedback. Yeah, I think that really made my day and made me very happy.
So when we’re looking at the relationships between doctoral candidates and supervisors, which I personally think are really important, how important do you think is a strong relationship between doctoral candidates on one side and their supervisors on the other side for a successful PhD?
I think successful in terms of going through the PhD with being liking what you do and being happy about what you do and really feeling that you have fulfilled what you’re doing and then also continue maybe with this work or similar work. I think for this, for most of the people, it’s quite essential. So I think I would never have made it through my PhD when I would not have known that I would have been in an amazing group with a strong supervisor and that’s also the feeling that I have with my group and the people I supervise that for us it’s quite important that we know each other well enough that also if someone has a bad day one can basically take care and feature that in. And that you know that you can come to your supervisor with any problem, issue and also amazing and great news. And you know, this person has a good relationship with you and understands you and react to it. And it’s not like a neutral person that gives remote information or not.
So a very human approach, we could say.
Yes, so I think for me the one fits all solution definitely doesn’t work. I like to figure out with everyone in the group, or with everyone at work actually, what the right type of interaction is. So some people just like to disappear for 10 days and be like, let me work and then I present. And then I think that’s the right approach for them and I’m happy to adapt to it. Others like to come in every day once or twice and just give quick updates and ask for feedback. And sometimes it also depends on the phase of the project. And I think most of the people, you know, if they’re in their safe zone and feel welcome and supported, they can do the best work that is possible. And that’s the state that I try to enhance and create.
Now, you already said that the one fits all solution doesn’t exist. Do you still think that there are some key factors that contribute to a successful relationship between the doctoral researchers and their supervisors?
Oh, yes. I think key factors, definitely. And I think this is about trust and also being emphatic about the other person and understanding their position and also their feelings and which type of pressure they sense at that moment. So I think in terms of the ingredients put together, this works basically in every situation and I would almost say it’s essential in any relationship. It’s just how to dose it and how much to use of which part and which station just depends on the person and the project.
Now let’s take a look at your personal ideal doctoral candidate. Are there specific qualities that doctoral candidates should have to work well with you as a supervisor and who would be the right fit in your research group?
I think for me what is relevant is someone is interested in the topic itself intrinsically and brings the right level of excitement. So I usually give a little bit of a speech at the beginning that I tell people that I’m not going to kind of carry them to the goal and that I’m not going to tell them how many hours they have to work or when they have to do what. I’m happy to support everyone and enable them but I will not micromanage or put up stringent timelines that they have to fulfill. So the self-drivenness I think is essential because I love my job a lot and I work with a lot of people that love what they do. And if someone actually does not want to work on a topic, I think this is creating a painful situation for both sides. And that’s nothing you can cover by, you know, pressuring people into certain parts of the work. So yeah, I think being highly motivated and self-driven and then being interested in the topic. And I think from that stage, we will agree on good terms how to work together.
When you’re having interviews for research positions for PhD candidates, how do you make sure that people actually have this intrinsic motivation in the topic? Is it just the smile on their face or is there other things that you consider?
I think it’s a good mixture of both sides probably. So it’s on the one side, I think it’s a lot of personal clicking. So I’ve hardly had the time that I met someone and was either not convinced in one or the other direction. So I believe into the gut feeling and sensing someone and getting a feeling that you get along well. And then finding the right project, because there are so many interesting things to work on. Not everyone needs to be interested in everything. So it’s getting well along with someone, feeling that they want to work on it, which usually correlates with someone approaching me, asking for a PhD position, having maybe read a paper, asking a few questions about certain things we do. And then the next half is basically figuring out if they know what they would like to do. And if not, collecting enough data points basically to design something to get started, to give them the option to learn what they’re actually curious about.
Many things of what you say, they touch on the fact that different people have different needs. Did you already encounter the situation that you had to adjust your approach as a supervisor? And if so, could you share an example?
So yes, I had a few occurrences in that direction, let’s say. So I think usually when it’s about master or bachelor theses, I think the intrinsic motivation is sometimes, or the idea that people think that they want something is not as developed as for a PhD position. So with bachelor and master students, I had this a few times that they were really not that much self-driven as they stated at the beginning. And then I had to adjust in a way that I gave like smaller snippets of information and basically told them a bit more in which direction it goes. But I think that’s a good learning example for them as well as for me, but especially for them to understand, okay, this is maybe not what I like. And I think that also reaches into the range of PhD students. And here I would say it’s not the student’s fault and neither the supervisor’s fault. Sometimes people don’t match. And I think at that stage it’s relevant to understand this early, because an unhealthy relationship between supervisor and PhD student over an extended period of three or four years, where both sides are frustrated, is simply extremely painful. So sensing this early and then rather seeing how to improve the situation, and that might include switching the group, is something that I, of course, don’t like to consider. But sometimes I think it helps both sides and improves the situation for everyone.
And when would be the best moment to do so? Right in the beginning when you realize something is off? Or do you think it’s worth waiting a while?
I think kind of a while. So usually, especially when you switch the country, the first few weeks might be simply different, and you might adjust to a new environment and everything. But then I would say within those first three to four months, you really sense if this is going to work out long term or not. And that’s also a timeframe where you can find options and search and also support the student by maybe finding a better option.
What do you think doctoral candidates can do wrong in their collaboration with their supervisors?
I think not being honest, at least in my experience, doesn’t work. So if you have the feeling, you know, you need to be a different person in the meeting and you cannot express what you actually think or feel, I think that’s a mistake because that means that the other person can also not adjust to you but maybe thinks everything is fine, everything is good and is not considering to change on their side. And I think for me it’s a matter of fairness that everyone is allowed to say I don’t like the following or I feel overwhelmed. And then it’s not about like, this is your fault or something, but work together to find a solution so that everyone gets again into the space where they can actually show that they are great researchers and proceed and grow.
Yeah, definitely. Now let’s change direction a little bit and move to another topic. I would like to know what was your childhood dream? What did you want to be when you were a child?
Yeah, that was for me a very constant dream. So I wanted to become a medical doctor. And I think I started with that dream really from really early childhood on that was very clear medical doctor it is. And it took quite a few years, actually, until Abitur, where I then started to realize that I found the knowledge you gain during this type of work and during the studies extremely interesting. But I actually never really wanted to work as a medical doctor, but wanted to do research in this direction. And yeah, that’s why I think also the perspective of my research group is a bit in that direction still. So it never stopped that this was a path I considered for a long time.
So after you started studying at university, did you know pretty much right away that the academic career was the right fit for you or was it a defining moment, a moment where you thought, okay, I’m definitely going to stay in research because that’s what I love?
Yeah, no, I think I was absolutely unsure what I wanted to do. So I studied biomathematics, so mainly mathematics with a bit of biology on top. And for a long term, I was actually not really sure what I wanted to do. So what I did was then going for a semester abroad, I went to New Zealand. And there in 2010, I worked the very first time with sequencing data. And that was incredibly fascinating for me. I figured out that you can actually read out the entire genomic context of a cell or content of a cell. And back then I thought, wow, now we can actually know everything about a cell and really understand how diseases arise and how things go wrong within a cell. Of course, it turned out that there are so many more layers that we couldn’t read out during that time and that we might be able to read out now, but still it’s way more complex than just sequencing. But that was for me a defining moment where I understood this is the type of research that I would like to do. And from then on, I was pretty sure that I would like to proceed with a PhD and also there see a bit what the next steps are.
So you didn’t have a plan going ahead? You weren’t sure yet if you want to have a professorship one day or not?
No, for a long time not. I think I during my PhD, I considered doing a postdoc simply because I was curious about what we were doing, but I was, I wouldn’t say afraid, but I had huge respect for the idea of actually running a group because that means that a lot of people are trusting me that I come up with cool ideas. How they can get started and then trust me that this will result in them having a PhD. And I found that this was, you know, it’s not only caring for me and my research and my career, but now taking over the responsibility for other people. This was something I did not consider during my PhD and it took a little while throughout my postdoc to actually grow into this role and understand that I like it a lot.
That would have been my next question. Now that you have the role and the responsibility as well, how does it make you feel?
Let’s say I did a relatively long postdoc and then slowly grow into the group leader role before I then started with a professor position. I had a lot of training time and also time to build up some confidence and also get the respective feedback from people I was working with. And now I enjoy working with a lot of excited young people, seeing how they grow, how their research starts from the beginning of the PhD and then develops throughout the time. So I think I’m in the happy place where I’m really doing what I like. And now I’m more confident that with the right motivation and the right team, the PhD for most of the people is an exciting and great time and not a scary and uncertain time.
Let’s imagine I were one of your doctoral candidates and wanted to become a professor. What would you advise me to focus on? Or maybe you would also say, let yourself grow into it, allow yourself to grow into it. Or would you say there’s something I should prioritize, be it publications, networking or maybe teaching?
I think there are hard and soft facts, basically. So I think on the soft side, I would say, don’t be afraid to fail. Find your own passion, what you want to do and try things out. And then you will find the topic you’re curious about. And once you have this, you will be able to do great research on it. So, you know, you will grow into the scientific role. And then, of course, these parts that are useful when you consider applying somewhere, which means, of course, papers count. I think that’s simply the type of money we deal with. But papers will fall into place if you do great research. So I think that part should grow over time. Then I would definitely say do some teaching because the role of a professor is not only supervising people and doing research, but the main part is about teaching. And if you don’t like it, neither you nor your students will enjoy the time where you are in the classroom. And I think that makes considerable parts of your life actually less enjoyable than they could be. Yeah, that’s why I would say teaching, testing that, seeing if you like it and how to become good at it is essential.
Yeah, I totally agree. And I’m happy that you mentioned it because I think teaching is often frowned upon a bit or people don’t like it as much. They think it just comes with the job. But yeah, I think the same as you just said that in order to be happy and fulfilled and to make your students and PhD candidates happy as well, it’s really important to also like that part of your job as a professor.
And I think it can actually be really fun. So I think if you do an exciting lecture, often the questions you get are pretty good questions and also coming from different angles than you were thinking about it. And sometimes you’re like, this is actually a really good idea. I haven’t thought about it. And also seeing people, you know, grow into the topic and become more interested about the parts you do. For me, that pays a lot back if you have an excited class there. Of course, it’s also exhausting if you talk straight for 90 minutes, that is exhausting physically. But for me, it pays back a lot to see that people are interested in what you’re doing and even consider pursuing that path of research.
Now looking back at your own PhD, what were the biggest challenges you faced and what, or maybe also who, helped you to overcome them?
I think for my PhD, some big challenges were that it was part of a larger consortium. So there were a lot of stakeholders and expectations. So I think my major challenge was basically me myself, because I needed to find my way of working in a larger group where everyone needed something and also gaining confidence that I was doing things correct and right. And I think the part that was a challenge was also helping me to overcome because I met a great number of people that really were super supportive and taught me a lot. And with them, I learned that I really like the type of interdisciplinary joint research, because once the knowledge of different expert domains comes together, you can learn way more about a disease or a cell state than you could do on your own.
You said that you had to find your own way of working. I’m very curious. What is your own way of working? What did you find?
I think my way of working is, first of all, seeing the other side and understanding their way of thinking and also their approaches and trying to find a good way of communication, because in my opinion, communication is really the key to most of the things. There are so many options how misunderstandings can happen, especially when you come from different domains, where you sometimes almost speak different types of languages. So the way a clinician phrases something, the bioinformatician might not understand at all, and the other way around. And I think all domains have things that are easy and work well, but all domains also have challenges. And if we do not understand the other side, it’s hard to really build integrative work.
I agree. Definitely. By the means of communication, a lot of misunderstandings can be discovered and avoided or solved. Now, another thing you said, which I also find very interesting, is that you had to gain confidence to do the things I think you said correctly and right. And I think that’s very interesting because in my experience, a lot of PhD candidates lack confidence which also might be due to experiences they had, a lot of criticism maybe. Do you have any tips for what people in a similar position could do to gain confidence?
I think finding a mentor or someone you trust helps a lot because your mentor doesn’t need to be always your supervisor because your supervisor has to have a look at the science and also be more critical. But if you have a mentor, that person might simply help you to explain less emotional both sides. And I think for me, usually positive reinforcement works quite well. So I don’t work that well with people just saying this and this is bad. So I think finding a good balance between, of course, criticizing and the friendly and nice way of things go wrong, because ignoring them usually doesn’t help. But on the other side, also telling people if they did something good and correct, so that they can build confidence on what they are doing. And learn to balance also the emotions on if they did something wrong. Because, you know, I think failing itself is not the big problem. Because if we don’t fail, we didn’t try things out of the box. And I think that’s part of research, trying things that are not streamlined and have been often done before. So I think supporting people on being allowed to fail and helping them then to get on a path where they can proceed. That’s how I think I myself build confidence on things. And I have the feeling that also works for a few other people.
Do you think that’s sometimes lacking in the academic field that people get encouraged, that they also get encouraged to make mistakes and learn from them?
I think it’s kind of also a natural way, especially if there’s a lot of pressure, that it’s easy to say, let’s not do any extra rounds, let’s not try something that is high risk. I can see how this sometimes is also like a, I wouldn’t say survival strategy, but a strategy that you need to do to get through harsh times. But for me, that’s where research starts, where it becomes interesting to try new things. So it wouldn’t be the type of research that I would like to do.
And you would miss out probably in a lot of interesting stuff.
Yeah, I mean, everything, of course, you know, if you don’t do high risk, you might be quicker at the goal that you might have put. The question is, is this the best goal that you could have reached? And I think balancing this a bit, of course, you cannot, like do only high risk and fail throughout five years, because this will also need to lead somewhere, right? So I think finding the fine balance between being able to try new things and be allowed to fail and not … You know, if a student fails on something, you don’t need to tell them that they did a bad job. They are frustrated themselves, right? So it’s not that you need to like negatively enhance this feeling because no one likes to fail anyway. So I think finding a good balance between trying out new things with the risk of failing, but then also picking up the person again and helping them to recover and get to the next steps. I think that’s the challenge, but also if it works, it comes with a lot of reward.
I think it became very obvious during the course of this interview that you’re very passionate about your job, about research. When your job is also your passion, it can be easy for working hours to spiral out of control. How do you maintain a healthy work-life balance? Or maybe that’s also something you’re still working on.
I think the healthy work-life balance is first of all probably defined for everyone in their own way. And what I try to usually communicate is that there are phases of more speed, more work, where you have a high phase, where something is more urgent. And I think this is good to learn to tolerate them and actually kind of maybe also to enjoy them. But I think for a healthy work-life balance, we need also the down faces on the other side, you know, where you work less, where you recover from the sprint that you have just done. And I think by this, for me, it doesn’t look like, you know, a flat line where I have every time the same or every day the same work-life balance throughout a week or a month or a year. But there are phases where you do more and then are phases that you do less. And I think I try to balance that a bit in a way that every time I’m excited, of course, I have no problems for myself to say, okay, I’m working more during this time, or I’m spending more time on it. But then also trying to find the phases, you know, where you do more maintenance, and balance these two sides.
Do you think those phases with less work, they’re naturally integrated into the course of academia or is that something you actually have to make sure that it’s happening and that there are those phases with lower work pressure as well?
I think it’s both. So I think for the students, it’s often something the supervisor needs to enforce at some point. Because it’s easy to keep someone in the high phase. But usually, you know, if you run a sprint, you can’t do six sprints in a row over the distance of a marathon, because, you know, this is not how you can balance energy. So I think for people that are easy to be excited and to be in the sprint, it also needs someone taking care to make sure they stay as healthy as it should be. I have to admit for myself, I’m less good in it, but I also don’t feel like I’m suffering from that at the moment. So I will find my phases, but yeah.
Professor Kretzmer, to wrap it up, let’s do a few quick questions, just short and spontaneous answers. It’s just a series of four or five questions I have for you. And I would ask you to just quickly answer with one word or it could be five words as well, but just a really quick and spontaneous answer.
Are you someone who likes to plan ahead or do you prefer to take things as they come?
I like to plan ahead, but I know this is not always possible.
In an ideal world, how many doctoral candidates would you like to supervise at the same time?
Four.
What do you enjoy most about leading a research group?
The joint work and also celebrating together the successes.
Do you have a role model in academia or in doctoral supervision?
Actually not.
Who is more responsible for a good relationship, the supervisor or the PhD candidate?
The supervisor.
Because?
Because the supervisor has way more information on most of the things, is way longer in the game and hopefully already, let’s say, emotionally more stable and experienced in doing research together.
And they also hold more power in the hierarchy of the university?
Absolutely, yes.
Is there anything else you would like to share with doctoral candidates, maybe also with other supervisors?
I think for doctoral candidates is mainly find a place where you think you can do great research, where you feel understood. And yeah, I would almost say happy. And then the research will fall into place.
Thank you so much for this conversation. It was very inspiring to hear about your experiences. Thank you so much for your time.
Thank you very much.
OUTRO
That was such an insightful conversation with Professor Dr. Helene Kretzmer, and I hope you enjoyed it as much as I did. We covered so much from the key principles of good supervision to practical advice for doctoral candidates, career planning for future professors, and even the role of failure and work-life balance in academia. One key takeaway? A strong PhD supervisor relationship isn’t just about research. It’s built on trust, communication, and understanding different working styles.
If you’d like to learn more about the DRS Supervision Award and past awardees, visit the Dahlem Research School podcast website. And if you enjoyed this episode, make sure to check out our other interviews with supervisor award wins, and discussions on key topics in the doctoral journey. This was Dr. Marlies Klamt for the DRS podcast, the podcast of Dahlem Research School at Freie Universität Berlin. Thanks for listening, and I hope you’ll join us again for our upcoming episodes.